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Frequently Asked Questions

Common questions about participating in a clinical research trial. If your question isn’t answered here, please don’t hesitate to contact us.

General Questions

A clinical trial is a medical research study that involves volunteers to help the medical field better understand and develop new ways to prevent, diagnose, and potentially treat diseases. This is the primary way researchers find out if a new treatment like a new drug or medical device is safe and effective.

There are many different types of clinical trials.
In a typical clinical trial, one group of volunteers receives the drug being studied, and another group of volunteers receives a placebo (also known as a “sugar pill” which looks or acts like the study treatment but has no therapeutic action) to compare the two groups.
In other trials, every volunteer may receive the drug or treatment being studied with no placebo involved.
Some studies involve investigational drugs, while other studies involve already approved FDA treatments.
Some clinical trials take place in an office setting, while others require volunteers to sleep overnight for monitoring.
Every protocol is different and Pillar Clinical Research is happy to explain and guide you through any potential studies you are interested in.

Comparing a study drug or treatment to a placebo often is the surest and most effective way to demonstrate the effectiveness of potential new treatments.

Some symptoms may improve even if a participant is not on the investigational medication. This is called the placebo effect. Thus, clinical trials try to collect information to determine if the study treatment is actually more effective than the power of placebo itself.

Interested volunteers are informed before they enter a trial whether placebos will be used in the study and the risks and benefits of the study medication(s).

Pillar Clinical Research sees it as a privilege to collaborate and work with research study volunteers. In our work together, we hope that your participation will help us better understand how the study drug or device works in different people. Some reasons to consider participating in a clinical trial:
  • Access to new drugs or devices that may not be available on the market.
  • Access to study medication or devices at no financial cost.
  • Satisfaction in potentially helping advance medical research.
  • Collaboration with your outpatient treatment team (with your consent).
  • Potential compensation for participating in a clinical trial.

Each clinical trial has its own specific set of criteria regarding who is or isn’t eligible to participate. For example, some of the criteria may be based on age, weight, what medications you are currently taking, how long you’ve had your illness, etc. So, not everyone who applies for a clinical trial will be eligible.

Once you contact Pillar, we will conduct a brief phone screen to see if a study may be a good fit for you. From there, we will set up a no-cost “Pre-Screening” interview. Transportation to this office interview can be provided. This in-person interview will help us determine whether or not you potentially qualify for a study. If you are a potential candidate, we will set up an official “screening” visit.

Once you arrive at the research site for your “screening” appointment, you will receive an “Informed Consent” document. This document provides a description of the research study, the potential risks, and benefits, your rights as a study participant, any agreed-upon compensation related to study participation, and emergency contact information. You will be given ample time to review this on your own in addition to having this reviewed with you by a designated research staff member. We will answer your questions and address any concerns so you can make an informed decision to consent or not or whether you’d like to think it over more before deciding. No research study-related procedures will be performed until informed consent is signed. You will be provided with a copy of the signed informed consent for your records

Screening Visit
Once you complete the informed consent document, the screening visit can begin. The purpose of a screening visit is to determine whether or not you meet all of the eligibility criteria to move forward in the research study. Every study differs to some degree in terms of what takes place at screening, but in general volunteers can expect:

Being Interviewed to Obtain Your Medical History Undergoing a physical exam and ECG (electrocardiogram) Getting your blood drawn and providing a urine sample for lab testing Filling out and/or getting interviewed for various health questionnaires and surveys

In most cases, it may take a few days to a week for the lab results to return, for your clinical history and surveys to be reviewed, and for the final determination about your eligibility to be made.

Study Visits
If you meet all of the criteria for entry into the study, you will return to the research site for a series of study related visits. Depending on the study, you may be receiving the study drug or placebo during this time frame. Some studies are “double blinded” meaning that it is unknown to you and the treatment team which group you are assigned to. While other studies are “open label” meaning that both you and the treatment will know exactly which group you are in. The overseeing study physician can find out exactly which group you are in, if needed, in the case of a medical emergency.

Study visits typically involve: periodic physical exams, completion of surveys and clinician guided surveys, ongoing lab work for medical safety monitoring.

The total number, frequency and length of visits depends on the study.

End-of-Study Visit
Once you have either completed the scheduled study visits, elected to withdraw from the study, or have been withdrawn for safety reasons, an End-of-Study Visit is conducted. In general, the procedures and assessments at an End-of-Study Visit are similar to what was conducted at your screening visit.

The research study staff will also discuss with you and coordinate with any of your outpatient providers (with your consent) to help determine your post-study treatment plans for followup. Some studies may require a “safety follow up visit” for further monitoring.

Safety Follow-Up Visit
The purpose of these more brief visits is to monitor for any possible lingering study related issues and to ensure that they are either clinically stable or resolved before your participation is completed.
Just as everyday activities and standard medical care carry potential risks, there are also potential risks involved in clinical research trials.
For example:
There is no guarantee you will directly benefit from participating in a study. Study drugs/devices may potentially cause adverse effects ranging from mild, to serious, to life threatening.
Not all of a study drug/device’s adverse effects may be known at the time you are enrolling for clinical trial.
The specific risks associated with any clinical research trial are described in detail in the Informed Consent document, which you are asked to review and sign before taking part in a study. In addition, the potential risks and benefits of participating in a study will be explained to you by a member of the research team, who will answer your questions about the study. It is important you understand and consider these risks before consenting to participate in a clinical trial.
In most clinical trials, all study-related visits, lab tests, medical assessments, and procedures are provided at no financial cost to the volunteer. In addition, you may potentially be compensated for your study participation. The specifics of such compensation will be described in the Informed Consent document.
Transportation to and from your home for both pre-screening visits and visits during a clinical research trial can be provided by Pillar Clinical Research. Don’t let transportation concerns stop you from reaching out to us.

About Our Studies


Pillar Clinical Research participates in clinical trials that involve novel investigational compounds as well as FDA approved products. Trials range from seeking volunteers who have not received any treatment for their current episode of depression to those who are currently getting treated but not responding well to their regimen. Follow our blog or social media for the most up-to-date info on open enrolling studies.


Pillar Clinical Research has expertise in conducting research studies for schizophrenia, “negative” symptom schizophrenia trials, cognitive impairment associated with schizophrenia trials, trials involving long-acting intramuscular and subcutaneous injections in both inpatient and outpatient settings. Follow our blog or social media for the most up-to-date info on open enrolling studies.

Bipolar Disorder Research

Bipolar Disorder clinical trials typically involve outpatient bipolar depression studies as well as inpatient acute manic/mixed episode studies. Follow our blog or social media for the most up-to-date info on open enrolling studies.

Substance Use Disorders Research

Clinical trials for substance use can range from studies involving alcohol use disorders, smoking cessation to opioid/opiate use disorder in both inpatient/outpatient settings. Follow our blog or social media for the most up-to-date info on open enrolling studies.

Healthy Volunteer

There are certain studies where healthy volunteers are needed. These types of studies are examining and learning about what a study drug and its chemical properties once someone takes them. Healthy volunteer studies may determine how long it takes the study medication to absorb or clear from the body, or what adverse issues are noted. Follow our blog or social media for the most up to date info on open enrolling studies.

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